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  • Title: The effect of combined gentamicin-corticosteroid treatment on gentamicin-resistant Pseudomonas keratitis.
    Author: Stern GA, Okumoto M, Friedlaender M, Smolin G.
    Journal: Ann Ophthalmol; 1980 Sep; 12(9):1011-4. PubMed ID: 6821445.
    Abstract:
    In an experimental model of Pseudomonas keratitis caused by a gentamicin-resistant strain of Ps aeruginosa, the results of treatment with gentamicin alone and a gentamicin-steroid combination were evaluated. Treatment with steroids did not reduce the amount of corneal inflammation when compared to eyes treated with gentamicin alone. Eyes treated with the gentamicin-steroid combination were, however, infected with a statistically significant greater number of organisms at the end of a 3-day treatment period. Corticosteroids probably should not be used in the treatment of Pseudomonas keratitis during the early period when the antibiotic sensitivities of the organism are not known.
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