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  • Title: Malignant Brenner tumor of the ovary. Electron microscopic study of a case responsive to radiation and chemotherapy.
    Author: Haid M, Victor TA, Weldon-Linne CM, Danforth DN.
    Journal: Cancer; 1983 Feb 01; 51(3):498-508. PubMed ID: 6821829.
    Abstract:
    A patient with malignant Brenner tumor of the ovary is presented. The tumor responded to combined therapy with radiation plus doxorubicin + cyclophosphamide despite earlier failure on a single alkylating agent (levophenylalanine mustard). The patient next exhibited a brief response to chemotherapy with hexamethylmelamine + cyclophosphamide + amethopterin + 5-fluorouracil. The histologic findings and ultrastructure of the tumor are discussed in detail. The morphologic features are consistent with the proposed origin of Brenner tumors from coelomic epithelium through a process of secondary urothelial metaplasia.
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