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  • Title: Lithium test-dose methodology using flame photometry: problems and alternatives.
    Author: Palladino A, Longenecker RG, Lesko LJ.
    Journal: J Clin Psychiatry; 1983 Jan; 44(1):7-9. PubMed ID: 6822488.
    Abstract:
    Two published methods of assessing test-dose 24-hour serum lithium concentrations as measured by flame emission spectrophotometry were compared in 17 patients. The first method was unsuccessful in predicting required maintenance dosage in 53% of patients studied. By applying the second methodology, a strong positive correlation (r = 0.69) was obtained between the reciprocal of the maintenance dose required to achieve a steady-state serum lithium concentration of 1.0 mEq/L and the test-dose 24-hour serum lithium level. Problems relating to the use of flame photometry to measure serum lithium concentrations less than 0.05 mEq/L are discussed.
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