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  • Title: Tryptophan transport into plasma membrane vesicles derived from rat brain synaptosomes.
    Author: Herrero E, Aragón MC, Giménez C, Valdivieso F.
    Journal: J Neurochem; 1983 Feb; 40(2):332-7. PubMed ID: 6822827.
    Abstract:
    Tryptophan uptake by membrane vesicles derived from rat brain was investigated. The uptake is dependent on the Na+ gradient [Na+] outside greater than [Na+] inside, and is maximal when both Na+ and Cl- are present. The uptake represents transport into an osmotically active space and not a binding artifact, as indicated by the effect of increasing the medium osmolarity. The uptake of tryptophan is stimulated by a membrane potential (interior negative) as demonstrated by the effects of the ionophores valinomycin and carbonyl cyanide m-chlorophenylhydrazone and anions with different permeabilities. Kinetic data show that tryptophan is accumulated by two systems with different affinities. Ouabain, an inhibitor of Na+,K+-activated ATPase, does not affect tryptophan transport. The uptake of tryptophan is inhibited by high concentrations of phenylalanine, tyrosine, leucine, and 3,4-dihydroxyphenylalanine.
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