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  • Title: Unfavorable neonatal outcome after intraamniotic injection of methylene blue.
    Author: McEnerney JK, McEnerney LN.
    Journal: Obstet Gynecol; 1983 Mar; 61(3 Suppl):35S-37S. PubMed ID: 6823393.
    Abstract:
    A case is presented in which methylene blue dye was injected intraamniotically to confirm rupture of the membranes. Significant neonatal morbidity occurred as a direct result of the methylene blue dye injection. A syndrome of toxic side effects is described including hemolytic anemia, hyperbilirubinemia, and methemoglobinemia. The metabolic process is discussed. The authors suggest discontinuing the intraamniotic injection of methylene blue dye as a diagnostic aid.
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