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  • Title: Hypoxic cell radiosensitization by moderate hyperthermia and glucose deprivation.
    Author: Kim JH, Kim SH, Hahn EW.
    Journal: Radiat Res; 1983 Feb; 93(2):416-20. PubMed ID: 6823521.
    Abstract:
    Cell culture studies were carried out to determine whether moderate hyperthermia reduces the oxygen enhancement ratio of cells under well-defined cultural conditions. Using asynchronously growing HeLa cells, the OER of cells with and without glucose was determined following exposure of cells to moderate hyperthermia, 40.5 degrees C for 1 hr, immediately after X irradiation. The OER of cells with 5 mM glucose was 3.2, whereas the OER of glucose-deprived cells was reduced to 2.0. The pH of the cell culture medium was kept at 7.4 throughout the experiments. The present finding may provide a clue toward further enhancing the radiosensitization of hypoxic cells by heat.
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