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  • Title: Human c-Ki-ras2 proto-oncogene on chromosome 12.
    Author: Sakaguchi AY, Naylor SL, Shows TB, Toole JJ, McCoy M, Weinberg RA.
    Journal: Science; 1983 Mar 04; 219(4588):1081-3. PubMed ID: 6823569.
    Abstract:
    A human colonic adenocarcinoma transforming gene, recently identified as a cellular homolog of the Kirsten sarcoma gene (v-ras), was used to assign the human cellular Kirsten ras2 gene to chromosome 12 by the Southern hybridization method. A single 640 base-pair Eco RI--Hind III fragment of the transforming gene, isolated by DNA transfection and molecular cloning, can detect a single Eco RI fragment (2.9 kilobase pairs) of DNA from phenotypically normal cells. The data suggest a constant chromosomal location of c-Ki-ras2.
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