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  • Title: Clostridium difficile cytotoxin in a pediatric population.
    Author: Thompson CM, Gilligan PH, Fisher MC, Long SS.
    Journal: Am J Dis Child; 1983 Mar; 137(3):271-4. PubMed ID: 6823926.
    Abstract:
    Assays for cytotoxin of Clostridium difficile were performed on stool samples submitted to the laboratory for routine microbiologic study. Cytotoxin was recovered from 8.6% of 208 pediatric patients studied. Cytotoxin was identified significantly more often in younger patients (median age, 11 months) and in those with hospital-associated illness (17%) and antibiotic-associated illness (18%). Hospitalization and antibiotic use were significant independent risk factors. Clinical diagnoses in patients with C difficile cytotoxin included classic pseudomembranous colitis, acute self-resolving diarrheal syndrome, chronic diarrhea with failure to thrive, infant botulism, and asymptomatic carriage.
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