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  • Title: Increased plasma MHPG in dexamethasone-resistant depressed patients.
    Author: Jimerson DC, Insel TR, Reus VI, Kopin IJ.
    Journal: Arch Gen Psychiatry; 1983 Feb; 40(2):173-6. PubMed ID: 6824413.
    Abstract:
    Severely depressed patients frequently show inadequate suppression of serum cortisol levels by dexamethasone. In a study of 15 depressed patients, we found a robust correlation between plasma levels of cortisol and 3-methoxy-4-hydroxy-phenylglycol after dexamethasone administration. These results suggest that dexamethasone resistance and adrenergic activation reflect parallel responses to illness-related stress in some depressed patients.
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