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  • Title: Antidepressant drugs, convulsions and epilepsy.
    Author: Richens A, Nawishy S, Trimble M.
    Journal: Br J Clin Pharmacol; 1983; 15 Suppl 2(Suppl 2):295S-298S. PubMed ID: 6824560.
    Abstract:
    1 Evidence concerning the convulsant effects of non-monoamine oxidase inhibitor antidepressant drugs has been reviewed. 2 Mianserin is convulsant in therapeutic doses but seizures have not been reported following overdose. 3 The convulsant effects of mianserin are probably no greater than for other non-monoamine oxidase inhibitor antidepressant drugs. 4 Enzyme-inducing anti-epileptic drugs can reduce the peak plasma concentration of mianserin and shorten its elimination half-life, probably by inducing its metabolism.
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