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  • Title: Isolation and physico-chemical properties of blood platelet alpha-actinin.
    Author: Landon F, Olomucki A.
    Journal: Biochim Biophys Acta; 1983 Jan 12; 742(1):129-34. PubMed ID: 6824676.
    Abstract:
    A procedure for the isolation of alpha-actinin from human blood platelets is described. Typical yields were 10-13 mg from 48 g of frozen platelets. The purified platelet alpha-actinin has many physico-chemical properties (molecular weight in native state, molecular weight in denaturing conditions, Stokes radius, ellipticities at 208 and 221 nm) similar to those of muscle alpha-actinins. However, in contrast to muscle alpha-actinins, it is composed of isoforms containing subunits of slightly different molecular weights and its effect on actin gelation is calcium-sensitive. These two characteristics are common to other known non-muscle alpha-actinins.
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