These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of synthetic oestrogens and progestagens in oral contraceptives on bile lipid composition.
    Author: Down RH, Whiting MJ, Watts JM, Jones W.
    Journal: Gut; 1983 Mar; 24(3):253-9. PubMed ID: 6826111.
    Abstract:
    The prevalence of cholesterol gall stones in young women has increased since the introduction of oral contraceptives. The synthetic female sex hormones used in these preparations, increase the degree of cholesterol saturation in bile. To determine whether oestrogens, progestagens, or both, are responsible for the change in biliary cholesterol saturation index, a prospective randomised, controlled study was performed. A significant increase in the cholesterol saturation index of bile was observed when either 30 micrograms ethinyloestradiol plus 150 micrograms norgestrel (p = 0.01) or 50 micrograms ethinyloestradiol plus 250 micrograms norgestrel (p less than 0.01) were ingested daily for two months. No change in the cholesterol saturation index was observed when 30 micrograms ethinyloestradiol alone, or 30 micrograms ethinyloestradiol plus 2.5 mg norethisterone were used. The mechanism for the increase in cholesterol saturation index did not appear to involve bile acid metabolism. These results indicate that the progestagen, norgestrel, and not as previously thought the oestrogen, ethinyloestradiol, is responsible for the increase in cholesterol saturation of bile which accompanies the use of oral contraceptives. The prevalence of cholesterol gall stones in young women has increased since the introduction of oral contraceptives. The synthetic female sex hormones used in these preparations increase the degree of cholesterol saturation in bile. To determine whether estrogens, progestagens, or both, are responsible for the change in biliary cholesterol saturation index, a prospective randomized, controlled study was performed. A significant increase in the cholesterol saturation index of bile was observed when either 30 mcg ethnylestradiol plus 150 mcg norgestrel (p=0.01) or 50 mcg ethinylestradiol plus 250 mcg norgestrel (p0.01) were ingested daily for 2 months. No change in the cholesterol saturation index was observed when 30 mcg ethinylestradiol alone, or 30 mcg ethinylestradiol plus 2.5 mg norethisterone were used. The mechanism for the increase in cholesterol saturation index did not appear to involve bile acid metabolism. These results indicate that the progestagen, norgestrel, and not as previously thought the estrogen, ethinylestradiol, is responsible for the increase in cholesterol saturation of bile which accompaines the use of oral contraceptives.
    [Abstract] [Full Text] [Related] [New Search]