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  • Title: Cefamandole-aminoglycoside therapy of experimental enterococcal endocarditis.
    Author: Weinstein AJ, Fieker D, Hall G.
    Journal: J Antimicrob Chemother; 1983 Jan; 11(1):61-7. PubMed ID: 6826487.
    Abstract:
    Cephalosporin-aminoglycoside therapy of human enterococcal endocarditis has been associated with a high incidence of clinical failure. The comparative efficacy of three cephalosporin antibiotics (cefamandole, cefazolin, and cephalothin), in combination with gentamicin, was studied in a rabbit model of enterococcal endocarditis. The cefamandole-gentamicin combination produced higher rates of cure, despite the administration of comparatively lower doses. Studies of antibiotic penetration into a fibrin thrombus indicated that cefamandole penetrated the thrombus readily. The greater efficacy of the cefamandole-gentamicin combination may be related to the superior penetration of cefamandole into the fibrin-rich vegetations of endocarditis.
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