These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Left ventricular wall stress in compensated aortic stenosis in children.
    Author: Donner R, Carabello BA, Black I, Spann JF.
    Journal: Am J Cardiol; 1983 Mar 15; 51(6):946-51. PubMed ID: 6829470.
    Abstract:
    It is known that children with aortic stenosis (AS) frequently have supernormal indexes of left ventricular (LV) pump function and remain compensated for many years. Factors causing this increase in pump performance have not been elucidated. A study was done on LV mechanics in 11 children with AS (aortic valve area 0.5 +/- 0.3 cm2/m2) and 10 normal subjects. The ejection fraction in the AS group (0.88 +/- 0.08) was significantly higher than in normal subjects (0.64 +/- 0.08, p less than 0.001). The mean velocity of fiber shortening was also higher in AS patients (1.80 +/- 0.35 circ/s) than in normal subjects (1.22 +/- 0.21 circ/s, p less than 0.001). The end-systolic volume index in patients with AS (9 +/- 8 ml/m2) was much lower than in normal subjects (27 +/- 8 ml/m2). LV mass in patients with AS was 180 +/- 58 g/m2 compared with 96 +/- 9 in normal subjects. LV wall stress was reduced throughout the cardiac cycle in patients with AS. Peak stress in patients with AS was 238 +/- 51 dynes/cm2 X 10(3) versus 439 +/- 85 in normal subjects. The end-systolic stress-end-systolic volume index ratio, an indicator of contractile state, was not elevated in patients with AS. It is suggested that diminished wall stress in concert with normal contractile function permits the supernormal pump function seen at rest in children with AS.
    [Abstract] [Full Text] [Related] [New Search]