These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Electrophysiological effects of myasthenic serum factors studied in mouse muscle.
    Author: Lerrick AJ, Wray D, Vincent A, Newsom-Davis J.
    Journal: Ann Neurol; 1983 Feb; 13(2):186-91. PubMed ID: 6830177.
    Abstract:
    Miniature end-plate potential (mepp) amplitudes were investigated in mouse diaphragm exposed in vitro to different serum fractions from seven patients with myasthenia gravis who had elevated serum anti-acetylcholine receptor antibody levels and from controls. The mepp amplitudes were significantly reduced by whole myasthenic sera, restored by washing, and not reduced by heated (56 degrees C) myasthenic sera, which would inactivate complement but not antireceptor antibody. Immunoglobulin G (IgG)-depleted myasthenic sera also significantly reduced mepp amplitudes, while the IgG fraction alone or with normal serum did not. The results indicate that in vitro reduction of mepp amplitudes in mouse muscle by myasthenic sera is not dependent on the IgG fraction alone, and requires a heat-sensitive factor.
    [Abstract] [Full Text] [Related] [New Search]