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  • Title: Tetrodotoxin inhibits the formation of refined retinotopography in goldfish.
    Author: Meyer RL.
    Journal: Brain Res; 1983 Feb; 282(3):293-8. PubMed ID: 6831250.
    Abstract:
    One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]proline injections simultaneous with either small (10-20 degrees sector) or half retinal mapping lesions. TTX had no effect on the time-course and quality of the regeneration of gross topography seen with half retina mapping, but indefinitely inhibited higher order (refined) retinotopography normally seen by 2 months with retina sector mapping.
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