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  • Title: Kinetics of taurocholate uptake by isolated ileal cells of guinea pig.
    Author: Schwenk M, Hegazy E, Lopez Del Pino V.
    Journal: Eur J Biochem; 1983 Mar 15; 131(2):387-91. PubMed ID: 6832157.
    Abstract:
    Carrier-mediated uptake of taurocholate by ileal cells of guinea pig had an activation energy of 66 kJ/mol. There was no distinct pH optimum in the physiological pH range. Uptake was efficiently inhibited by cholate and taurochenodeoxycholate in a competitive manner, but less inhibited by bromosulfophthalein and not inhibited by taurine. The rate of uptake was related to the extracellular Na+ concentration up to 90 mM Na+. Stimulation by Na+ (up to sevenfold) occurred only in the presence of a transmembrane Na+ gradient, whereas high extracellular (Na+) in the absence of gradient did not stimulate. It is suggested that taurocholate is bound to a steroid-binding site of the carrier. The energy for the intracellular accumulation is largely provided by cotransport with Na+.
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