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  • Title: Multiple hepatitis attacks with immunothrombocytopenia in a heroin addict.
    Author: Heer M, Pirovino M, Bühler H, Altorfer J, Schmid M, von Felten A.
    Journal: Hepatogastroenterology; 1983 Feb; 30(1):12-4. PubMed ID: 6832695.
    Abstract:
    A 25-year-old heroin-addict had four episodes of acute hepatitis, each of them associated with thrombocytopenia. Serologically, hepatitis A and B as well as cytomegalo- or Epstein-Barr virus infections were excluded. High levels of circulating immune complexes and antibodies reacting with aminophospholipids, a component of both liver cell and platelet membranes, were detected during the last two attacks of hepatitis, but were absent during remission. Platelet-associated antibodies of the IgM class paralleled the 'anti-phospholipid' antibodies during the fourth attack. These findings demonstrate an immunological basis of the thrombocytopenia and point to the possibility of a direct association between liver cell injury and peripheral platelet destruction in certain patients.
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