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  • Title: Localization of carcinoembryonic antigen in mesenteric lymph nodes of patients with gastrointestinal cancer.
    Author: Michalak T, Krawczyński K, Harłozińska A, Potomski J, Albert Z.
    Journal: Neoplasma; 1983; 30(1):67-72. PubMed ID: 6835439.
    Abstract:
    Mesenteric lymph nodes obtained at surgery from 36 patients with gastrointestinal tract cancer were studied by immunofluorescence for the presence of carcinoembryonic antigen (CEA). Granular deposits of CEA in a homogenous mixture with immunoglobulins and complement were detected in the activated germinal centers in 12 lymph nodes from 8 investigated cases. Identification of CEA in germinal centers was confirmed by blocking and absorbtion procedures. Successful elution of immunoglobulins and part of CEA content with a buffer known to dissociate antigen-antibody bonds suggested that these deposits represent CEA immune complexes.
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