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  • Title: [Influence of macrophage culture supernatants on erythroblastic islets in rat erythropoiesis].
    Author: Zakharov Y, Prenant M.
    Journal: Nouv Rev Fr Hematol (1978); 1983; 25(1):17-22. PubMed ID: 6835833.
    Abstract:
    The isolation of central macrophages from erythroblastic islands (EI) permitted analysis of the role of EI macrophage factors in erythropoiesis. EI macrophage supernatant and peritoneal macrophage supernatant both had a similar effect on erythropoiesis. They exerted an erythropoietin-like effect. We observed changes in the number of erythroblasts per island; their distribution within each island during the maturation process was described. The role of the central macrophage in EI was discussed. We suggested a direct transfer of an erythropoietin-like activity to the erythroblasts which increases the efficacy of stimulation.
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