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  • Title: Podophyllin poisoning. Systemic toxicity following cutaneous application.
    Author: Slater GE, Rumack BH, Peterson RG.
    Journal: Obstet Gynecol; 1978 Jul; 52(1):94-6. PubMed ID: 683634.
    Abstract:
    The toxicity of topically applied podophyllin in a 16-year-old girl is presented. Coma requiring respiratory support and major neurologic complications as well as hematologic and hepatic toxicity was observed. Therapy with a new modality, charcoal hemoperfusion, resulted in resolution of the acute toxicity, leaving a peripheral neuropathy which had not completely resolved after 4 months. The pharmacology and suggested treatment measures for the toxicity of this rarely reported agent are reviewed.
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