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  • Title: Copper-binding proteins in the liver and kidney from the patients with Menkes' kinky hair disease.
    Author: Yazaki M, Wada Y, Kojima Y, Tanaka A, Isshiki G, Kawamura N, Hirose M.
    Journal: Tohoku J Exp Med; 1983 Jan; 139(1):97-102. PubMed ID: 6836561.
    Abstract:
    Copper-binding proteins in the tissues from the patients with Menkes' kinky hair disease were examined by gel filtration on a Sephadex G-75 column. In the kidney, major part of copper was found to bind to low molecular weight protein, which corresponded chromatographically to metallothionein. This copper-binding protein contained a large amount of copper and a small amount of zinc. Cu: Zn ratio of this protein was different from that of metallothionein found in the fetal liver. In the liver of the same patient, however, there was no increase of copper bound to this protein.
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