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  • Title: Congenital hypothyroidism: age at start of treatment versus outcome.
    Author: Virtanen M, Mäenpää J, Santavuori P, Hirvonen E, Perheentupa J.
    Journal: Acta Paediatr Scand; 1983 Mar; 72(2):197-201. PubMed ID: 6837293.
    Abstract:
    We studied 27 patients with congenital hypothyroidism by neurological and psychometric methods. 7 healthy siblings served as a control group for the psychometric evaluation. In 7 patients treatment had been started before the age of 1 month and in 10 patients after the age of 3 months. Our findings suggest that the progressive loss of intelligence potential starts from birth but if treatment is begun before the age of 1 month, then intelligence remains within normal range. The neurological damage seems to originate partly before birth, but more serious injuries arise if treatment is delayed beyond the age of 3 months.
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