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  • Title: Morphological changes in the hypothalamic arcuate nucleus and median eminence in the golden hamster during the neonatal period.
    Author: Lamperti A, Mastovich J.
    Journal: Am J Anat; 1983 Feb; 166(2):173-85. PubMed ID: 6837485.
    Abstract:
    The purpose of the present investigation was to study the ultrastructure of the arcuate nucleus (ARC) and median eminence of hamsters on days 1-15 of the neonatal period. From days 1-6, the neurons of the ARC had large nuclei and a small amount of cytoplasm which contained polysomes, mitochondria, RER, lysosomes and Golgi complexes. From days 7-15 there was an increase in the amount of cytoplasm as well as more extensive Golgi complexes and RER. Astrocytes were the predominant glial component in both the ARC and median eminence. Astrocytic processes were in juxtaposition to unmyelinated axons, dendrites, and synapses. Axodendritic and axosomatic synapses containing clear vesicles were observed in the neuropil on day 1. There was an increase in the number of dense-core vesicles in the axonal endings beginning on day 4. Concomitantly, there were increasing numbers of clear and dense-core vesicles (64-70 nm) in terminals of the external layer of the median eminence, whereas larger dense-core vesicles (105-140 nm) were distinguishable by day 10 immediately dorsal to the external layer. The capillaries of the median eminence were composed of nonfenestrated endothelium from days 1-9. Fenestrae began to appear about day 10. Ependymal cells lining the third ventricle had pinocytotic vesicles, microvilli, and bleb-like protrusions on their apical surfaces. Ependymal processes were adjacent to nerve processes in the neuropil of the ARC and in the external layer of the median eminence, where they contacted the perivascular space. Two types of supraependymal cells were seen in animals throughout the neonatal period. One resembled a neuron which sent processes along the ependymal surface and often between cells. The second type was similar to a macrophage. The results of this study demonstrate the maturation of the neural elements in the ARC/median eminence area of the neonatal hamster.
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