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  • Title: Absence of prolonged benefit of initial leukapheresis therapy for hairy cell leukemia.
    Author: Golomb HM, Kraut EH, Oviatt DL, Prendergast EJ, Stein RS, Sweet DL.
    Journal: Am J Hematol; 1983 Feb; 14(1):49-56. PubMed ID: 6837568.
    Abstract:
    Four patients with the leukemic phase of hairy cell leukemia were treated with leukapheresis. Two patients failed to respond, and the other two had only transient responses; hematologic improvement lasted one month in one case and four months in the second. The patient with a four-month response underwent a second series of leukapheresis resulting in a response lasting at least 8 months. Two of the four patients subsequently had an adequate trial of prolonged chlorambucil therapy and continued to have a clinical response. We conclude that leukapheresis has little to offer to the majority of hairy cell patients for the long-term management of post-splenectomy patients who develop the leukemic phase. However, an occasional patient can have a transient, and even, rarely, a prolonged response.
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