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  • Title: Essential thrombocythemia: a clonal disorder of hematopoietic stem cell.
    Author: Singal U, Prasad AS, Halton DM, Bishop C.
    Journal: Am J Hematol; 1983 Apr; 14(2):193-6. PubMed ID: 6837574.
    Abstract:
    We studied 5 patients with essential thrombocythemia utilizing glucose-6-phosphate dehydrogenase (G-6-PD) enzyme as a cell marker for determining clonality. One of the patients was found to be heterozygous for isoenzymes B and A in the nonhaemopoietic tissues such as fibroblasts, but manifested only isoenzyme type B in the erythrocytes, neutrophils, and platelets. Our studies support the concept that essential thrombocythemia is a clonal disorder arising in a multipotent stem cell.
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