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  • Title: Familial paroxysmal dystonic choreoathetosis and response to alternate-day oxazepam therapy.
    Author: Kurlan R, Shoulson I.
    Journal: Ann Neurol; 1983 Apr; 13(4):456-7. PubMed ID: 6838177.
    Abstract:
    A patient with familial paroxysmal dystonic choreoathetosis (FPDC) who was only transiently improved on daily benzodiazepine therapy showed sustained benefit from a regimen of alternate-day oxazepam therapy. Our findings confirm that FPDC is responsive to benzodiazepine therapy and suggest that an alternate-day dosing schedule, using a short-acting benzodiazepine, may minimize receptor down regulation and thereby sustain the therapeutic effect.
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