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  • Title: Dexamethasone affects phosphatidylinositol synthesis and degradation in cultured human embryonic cells.
    Author: Grove RI, Willis WD, Pratt RM.
    Journal: Biochem Biophys Res Commun; 1983 Jan 14; 110(1):200-7. PubMed ID: 6838510.
    Abstract:
    Dexamethasone (DEX), a glucocorticoid which induces cleft palate, causes marked alterations in the synthesis and degradation of phosphatidylinositol (PI) but not phosphatidylcholine in an established fibroblastic cell line derived from a human embryonic palate. Incorporation of radiolabeled inositol into phosphatidylinositol as well as degradation of prelabeled phosphatidylinositol is stimulated by DEX. The dose-response curves for the DEX-induced effect on PI synthesis and DEX-induced inhibition of cell proliferation are nearly identical, with the maximal responses occurring at 10(-8)M DEX. Our results suggest that DEX-induced inhibition of human embryonic palatal mesenchyme cell proliferation and alterations in synthesis and degradation of phosphatidylinositol are related.
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