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  • Title: Subcellular distribution of gamma-hydroxybutyrate binding sites in rat brain principal localization in the synaptosomal fraction.
    Author: Maitre M, Rumigny JF, Cash C, Mandel P.
    Journal: Biochem Biophys Res Commun; 1983 Jan 14; 110(1):262-5. PubMed ID: 6838515.
    Abstract:
    gamma-Hydroxybutyrate binding sites, first described on crude membranes from rat brain, have been further studied on subcellular fractions. The nerve ending fraction (fraction C) exhibits the maximal capacity for GHB binding. The two classes of binding sites (high and low affinities) described for the crude membrane preparation are enriched in this synaptosomal fraction. This result is further evidence in favor of a role for GHB as a neurotransmitter or neuromodulator in rat brain.
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