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  • Title: Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite.
    Author: Touqui L, Jacquemin C, Vargaftig BB.
    Journal: Biochem Biophys Res Commun; 1983 Feb 10; 110(3):890-3. PubMed ID: 6838557.
    Abstract:
    3H-PAF-acether (Alkyl-[1', 2'-3H]- 2-acetyl-sn-glyceryl-3-phosphorylcholine) was time-dependently transformed by plasma-free rabbit platelets into an unknown product, "PX", which was distinct from lyso-PAF-acether. This effect was specific for platelets since plasma only converted 3H-PAF-acether into lyso-3H-PAF-acether and platelets were not effective in metabolizing lyso-3H-PAF-acether. Platelet aggregation did not interfere with the formation of "PX". The latter is a novel platelet metabolite of PAF-acether with as yet unknown biological properties.
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