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  • Title: Effect of ovarian hormones on the induction of 1-methyl-1-nitrosourea-induced mammary cancer.
    Author: Grubbs CJ, Peckham JC, McDonough KD.
    Journal: Carcinogenesis; 1983; 4(4):495-7. PubMed ID: 6839422.
    Abstract:
    The concomitant administration of 20 micrograms 17 beta-estradiol and 4 mg progesterone/injection (5 days/week) over a 40-day treatment period beginning 10 days after methylnitrosourea (MNU) treatment was as effective as ovariectomy in inhibiting mammary cancers (an 84% reduction from non-hormone treated rats). The primary action of the hormones must have been directed at preneoplastic cells since the hormones were not given until 10 days after MNU (a direct-acting carcinogen with a short half-life).
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