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  • Title: Chronic idiopathic polyneuritis.
    Author: Sluga E, Poewe W.
    Journal: Clin Neuropathol; 1983; 2(1):31-41. PubMed ID: 6839574.
    Abstract:
    Clinical assessment, CSF changes, electrophysiologic findings, and nerve biopsy investigations are reported for ten cases of chronic idiopathic polyneuritis. Seven cases developed a progressive, three a relapse course. Motor deficit syndromes predominated, often with proximal weakness. Sensory signs were less frequent and less intense, although exceptions were noted. Elevated CSF total protein and a disproportional increase in IgG developed, which increased with duration of the disease. Nerve conduction velocity was markedly reduced. Nerve biopsies showed cell-mediated demyelination, simultaneous de- and remyelination, considerable alteration of Schwann cells, and long-persisting glycolipid-rich myelin degradation products. Particular features of chronic polyneuritis are delineated. The demyelinating process seems to be "self-perpetuating" and not monophasic as the acute forms. Schwann cells or their surface antigens seem to be targets of the immune response. Chronic polyneuritis responds to treatment with corticosteroids. Long-term treatment in combination with immunosuppressants and plasmapheresis is often required.
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