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  • Title: [Study of the insulin-receptor interaction on the plasma membranes of rat liver].
    Author: Liubarskaia SG.
    Journal: Probl Endokrinol (Mosk); 1978; 24(4):61-4. PubMed ID: 683973.
    Abstract:
    The radioreceptor method was applied to the study of specific insulin binding on the plasma membranes of the rat liver. Highly purified plasma membranes were obtained and conditions of their incubation with insulin were worked out for this purpose. Two types of insulin receptors were revealed: the first one with Cass=3.8( +/- 0.4)x10(11)M-1 and binding capacity=0.7( +/- 0.1) pM/mg; the second one--with less relationship of Cass=8( +/- 1)x10(10)M-1 and binding capacity=5( +/- 0.7) pM/mg.
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