These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Endocrine properties of RMI 12,936, an antiprogestational steroid. Author: Johnston JO, Grunwell JF, Benson HD, Petrow V. Journal: Contraception; 1983 Jan; 27(1):95-110. PubMed ID: 6839763. Abstract: RMI 12,936 (17 beta-hydroxy-7 alpha-methyl-5-androstene-3-one) exhibited postcoital contragestative activity at 10 mg/kg in hamsters. The endocrinological profile was determined for this steroid. This antifertility agent had significant antiprogestational, antiuterotrophic and gonadotropin-inhibiting activity. RMI 12,936 also exhibited weak uterotrophic and androgenic properties when given to immature gonadectomized rats. Hormonal antagonism and weak estrogen agonist properties would appear to contribute to the contragestative activity of RMI 12,936 in hamsters.[Abstract] [Full Text] [Related] [New Search]