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  • Title: Altered hindlimb extension in the rat after DSP-4: a useful marker of central noradrenergic depletion.
    Author: Mogilnicka E, Dooley DJ, Boissard CG, Delini-Stula A.
    Journal: Eur J Pharmacol; 1983 Feb 18; 87(2-3):345-7. PubMed ID: 6840195.
    Abstract:
    Rats treated with DSP-4, a selective noradrenergic neurotoxin, usually exhibited an attenuation of hindlimb extension when suspended by the tail. Those animals showing the reduced extension had no post-decapitation reflex (PDR), whereas those animals having a normal extension had the PDR. On this basis, rats injected with DSP-4 can be readily screened for an effective or ineffective noradrenergic lesion. Preliminary evidence suggests that the alpha 2-adrenoceptor is involved in the regulation of hindlimb extension.
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