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  • Title: Concentration-dependent differential effect of retinoic acid on intercellular metabolic cooperation.
    Author: Shuin T, Nishimura R, Noda K, Umeda M, Ono T.
    Journal: Gan; 1983 Feb; 74(1):100-5. PubMed ID: 6840430.
    Abstract:
    A vitamin A analog, 13-cis-retinoic acid (13-cis-RA), was tested for effect on intercellular metabolic cooperation between 6-thioguanine-resistant and -sensitive V79 Chinese hamster cells. Most typical tumor promoters have been reported to inhibit metabolic cooperation. 13-cis-RA was found to enhance metabolic cooperation of cells treated with a potent tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate. However, inhibition of metabolic cooperation was noticed when 13-cis-RA was used at higher concentrations.
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