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  • Title: An animal model of trachoma: IV. The failure of local immunosuppression to reveal inapparent infection.
    Author: Taylor HR, Johnson SL, Schachter J, Prendergast RA.
    Journal: Invest Ophthalmol Vis Sci; 1983 May; 24(5):647-50. PubMed ID: 6841015.
    Abstract:
    Repeated inoculation with live chlamydia trachomatis is necessary to develop a model of trachoma in monkeys. However, it is not possible to reisolate chlamydia from the monkey's eye after the first 1 or 2 months of weekly reinoculation. The effect of subconjunctival steroid injections in monkeys that had received weekly inoculations with live chlamydia is reported. Despite a profound suppression of local inflammation, steroid treatment did not produce a reactivation of identifiable chlamydial infection as determined by repeated chlamydial cultures and cytologic examinations.
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