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  • Title: Muscarinic cholinergic receptors on circulating human lymphocytes: evidence for a particulate binding site.
    Author: Bidart JM, Moingeon P, Bohuon C.
    Journal: Res Commun Chem Pathol Pharmacol; 1983 Jan; 39(1):169-72. PubMed ID: 6844735.
    Abstract:
    Lymphocytes from thirteen normal volunteers were investigated for their muscarinic cholinergic receptors content. A particular binding site was characterized with 3H-quinuclidinyl benzilate; saturation binding occurred at 80 X 10(-9)M and scatchard analysis provided a dissociation constant of 40 X 10(-9)M. These results showed that there were about 4000 muscarinic receptors on human lymphocyte. Although, it is possible to demonstrate the presence of binding site on a particulate preparation, the significance of such low-affinity receptor is yet unclear.
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