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  • Title: Vitamin K content of liver and feces from vitamin K-deficient and butylated hydroxytoluene (BHT)-treated male rats.
    Author: Suzuki H, Nakao T, Hiraga K.
    Journal: Toxicol Appl Pharmacol; 1983 Jan; 67(1):152-5. PubMed ID: 6845355.
    Abstract:
    Vitamin K content of liver and feces from male rats fed diets containing butylated hydroxytoluene (BHT) was estimated by a chick bioassay method to investigate the mechanism of BHT-induced decreases in the activities of vitamin K-dependent clotting factors. The concentration of vitamin K in the liver of rats receiving BHT was reduced as compared to that of control rats. Conversely, the concentration of vitamin K in the feces from rats receiving BHT increased more than that from control rats. The vitamin K deficiency induced by BHT might be due to effects of BHT on absorption and excretion of vitamin K.
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