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  • Title: [Frequency of sister chromatid exchanges in oncological patients during treatment with cyclophosphane].
    Author: Debova GA, Sapacheva VA, Filippova TV.
    Journal: Tsitol Genet; 1983; 17(1):65-9. PubMed ID: 6845422.
    Abstract:
    The sister chromatid exchange (SCE) level in patients with cancer of lungs before treatment did not differ from the mean number of SCE in healthy donors. In the process of a cyclophosphane treatment the SCE frequency in the patient lymphocyte culture increased with the drug doses of 4 and 5 g. Analysis of the ratio of cells in mitoses I, II and III revealed no differences in the cell cycle rate for groups of healthy donors, patients before the treatment, and treated patients.
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