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  • Title: [Concentrations of carbohydrate components of glycoproteins in rat serum and erythrocyte and leukocyte membranes in hyperthyroidism].
    Author: Kuz'mak NI.
    Journal: Ukr Biokhim Zh (1978); 1983; 55(2):151-7. PubMed ID: 6845441.
    Abstract:
    The content of carbohydrate components of glycoproteins in blood serum and erythrocyte and leucocyte membranes was studied as affected of various doses of L-thyroxin. It is established that administration of L-thyroxin small doses increases the level of glycoprotein components in blood serum and cells. Administration of median and especially of high doses of the hormone already on the 12th of the experiment lowers sharply the components level in blood serum and increases it in the membranes of erythrocytes and to a less extent in the membranes of leucocytes. By the 24th day of the experiment the total content of carbohydrate components in the membranes decreases (16.3-25.7% below the normal level). A moderate positive correlation is established between the changes in the content of certain components of glycoproteins in the blood serum and cell membranes in rats with hyperthyreosis induced by administration of L-thyroxin small doses. In the rest cases such a regularity is observed only between the indices in the blood cell membranes.
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