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  • Title: Progressive supranuclear palsy: clinical features and response to treatment in 16 patients.
    Author: Jackson JA, Jankovic J, Ford J.
    Journal: Ann Neurol; 1983 Mar; 13(3):273-8. PubMed ID: 6847139.
    Abstract:
    Among 415 patients with parkinsonism, 16 (3.9%) had findings of progressive supranuclear palsy (PSP). This report reviews the clinical features and response to drug therapy in those 16 patients. Anticholinergic drugs failed to benefit any of the 5 patients treated, while presynaptic dopaminergic drugs (Sinemet or amantadine) were beneficial in only 5 of 22 patient trials. Alternatively, dopamine agonists (bromocriptine and pergolide) caused improvement in 9 of 14 patient trials despite the fact that all but 1 of these patients had previously failed to respond to presynaptic dopaminergic drugs. Dopamine agonists such as bromocriptine and pergolide may be useful in some patients with PSP.
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