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  • Title: [Effect of copper sulphate on nucleic acid level in tissues of normal rats and those with leucosis].
    Author: Mazepa IV.
    Journal: Ukr Biokhim Zh (1978); 1978; 50(4):484-8. PubMed ID: 684876.
    Abstract:
    Dynamics of the DNA and RNA level was studied in tissues of rats normal and with leucosis. The effect of copper in biotic doses on the level under and analogous conditions of the experiment was investigated as well. In the process of leucosis formation the content of DNA and RNA increases in the liver, tumour and spleen. In the muscle tissues the DNA level is significantly higher on the 4th, 7th and 11th day of the experiment, the RNA level is higher only in the period of formed leucosis (on the 11th day). Additional administration of copper in biotic doses to leucoses affected and healthy rat causes essential shifts in the level of DNA and RNA. In the leucosis affected rats the effect of copper sulphate is pronounced in an increase in the DNA and RNA content in the liver and tumour and DNA content--in the spleen as well as in a decrease in the level of RNA in muscles and of DNA in the muscles and spleen tissue in certain periods of the disease. In healthy rats the shifts in the DNA and RNA content with additional administration of copper are not the same but in most tissues they manifest a pronounced tendency to an increase.
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