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  • Title: Topical epinephrine and regional ocular blood flow in aphakic eyes of rabbits.
    Author: Morgan TR, Mirate DJ, Bowman K, Green K.
    Journal: Arch Ophthalmol; 1983 Jan; 101(1):112-6. PubMed ID: 6849643.
    Abstract:
    The effects of 4% topical epinephrine bitartrate on regional ocular blood flow were studied in normal, "sham-operated," and aphakic eyes of rabbits. Anterior uveal blood flow decreased in all cases, but reductions in the ciliary processes were less pronounced in aphakic eyes than in sham-operated eyes. Doubling the dose (from 2 to 4 drops) abolished this difference in the ciliary processes, but the increased dose was accompanied by the emergence of a similar (although lesser) effect in the iris. The latter dose additionally decreased retinal blood flow in aphakic eyes compared with the sham-operated eyes. Lens extraction, thus, seems to remove a notable diffusion barrier to topical epinephrine, resulting in both attenuation of its anterior segment effects and in potentiation of a vasoconstrictive response in the posterior pole.
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