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  • Title: The effect of digoxin on 86rubidium uptake by erythrocytes from mothers and babies.
    Author: Kelly JG, McMillen RM, McDevitt DG.
    Journal: Br J Clin Pharmacol; 1983 Jan; 15(1):49-53. PubMed ID: 6849744.
    Abstract:
    1 The uptake of 86rubidium by erythrocytes from mothers and babies has been used as a model system to investigate possible differences in sensitivity to digoxin in the very young. 2 While total 86rubidium uptake was not significantly different between mothers and babies, the digoxin-sensitive proportion was higher in neonatal erythrocytes. Neonatal cells were less sensitive to digoxin, demonstrated by the requirement for a larger amount of digoxin to inhibit 86rubidium uptake and this was accompanied by an increase in numbers of specific erythrocyte binding sites for digoxin. 3 These results provide further evidence in support of the hypothesis of decreased sensitivity to digoxin in the very young.
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