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  • Title: [Effect of eserine on DNA synthesis in rat liver].
    Author: Elaeva NL, Stroikov IuN.
    Journal: Vopr Med Khim; 1978; 24(4):461-4. PubMed ID: 685189.
    Abstract:
    Incorporation of labelled precursors into total and nuclear DNA of liver tissue was inhibited after administration into animals of eserine at a dose 0.1--0.2 mg/100 g of body weight. Simultaneously, DNAase activity was increased and cholinesterase activity was inhibited in liver tissue. The DNA synthesis was inhibited in liver slices, if they were incubated with 2.10(-6) M eserine. The DNAase activity was unaltered in vitro. A cholinolytic compound metacin, pre-administered into the animals, was ineffective at dose of 1 mg/kg; it slightly decreased the effect of eserine at dose of 0.25 mg/kg.
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