These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Oral contraceptive steroids impair the elimination of theophylline.
    Author: Roberts RK, Grice J, McGuffie C, Heilbronn L.
    Journal: J Lab Clin Med; 1983 Jun; 101(6):821-5. PubMed ID: 6854122.
    Abstract:
    The influence of OCS and sex differences on the disposition of theophylline has been studied in 12 healthy young men (29 +/- 4 years old), 13 healthy young women (29 +/- 12), and 10 healthy young women (24 +/- 3) receiving OCS for a period greater than 6 months. The elimination t1/2 was longer in women taking oral contraceptives (523 +/- 110 min) than in women not on oral contraceptives (386 +/- 157). Weight-normalized plasma clearance of theophylline was less in women taking oral contraceptive steroids (0.70 +/- 0.15 ml X min-1 X kg-1) than in women not on oral contraceptive steroids (0.98 +/- 0.32). Plasma binding and volume of distribution were not different between the two groups of women. Weight-normalized clearance, weight-normalized volume of distribution, plasma t1/2, and plasma binding were not different between men and women not taking OCS. The influence of oral contraceptives (OCs) and sex differences on the disposition of theophylline has been studied in 12 healthy young men (29 +or- 4 years old), 13 healthy young women (29 +or- 12), and 10 healthy young women (24 +or- 3) receiving OCs for a period greater than 6 months. The elimination 1/2-life was longer in women taking OCs (523 +or- 110 minutes) than in women not taking OCs (386 +or- 157). Weight-normalized plasma clearance of theophylline was less in women taking OCs than in women not on OCs. Plasma binding and volume distribution were not different between the 2 groups of women. Weight-normalized clearance, weight-normalized volume of distribution, plasma 1/2-life, and plasma binding were not different between men and women not taking OCs.
    [Abstract] [Full Text] [Related] [New Search]