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  • Title: Salt-induced conformational transition of poly[d(A-T)] X poly[d(A-T)].
    Author: Vorlícková M, Kypr J, Sklenár V.
    Journal: J Mol Biol; 1983 May 05; 166(1):85-92. PubMed ID: 6854636.
    Abstract:
    Unique chiroptical properties of poly[d(A-T)] X poly[d(A-T)] observed in CsF solutions (Vorlícková et al., 1980) were specified by circular dichroism, ultraviolet light and 31P nuclear magnetic resonance spectroscopy. It was found that up to a 3 M concentration of the salt, caesium cations induced a gradual rearrangement of the polynucleotide double helix during which the phosphodiester bonds in one sequence changed the geometry and the base stacking decreased. At higher CsF concentrations poly[d(A-T)] X poly[d(A-T)] underwent a transition toward a novel conformation which had phosphodiester bonds in both sequences in considerably different non-B-DNA geometries.
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