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  • Title: Clofibrate decreases jejunal cholesterol synthesis and activity of postheparin plasma lipoprotein lipase in the rat.
    Author: Strandberg TE, Kuusi T, Tilvis RS, Miettinen TA.
    Journal: Pharmacology; 1983; 26(5):290-6. PubMed ID: 6856670.
    Abstract:
    Clofibrate treatment decreased drastically the activity of serum postheparin lipoprotein lipase of rats fed with fat-free test diet but had no effect on hepatic lipase. 3 weeks' treatment was followed by a significant fall in serum cholesterol caused by a marked decrease in HDL-cholesterol. Clofibrate decreased in vitro synthesis of cholesterol and fatty acids in jejunal villous cells but not in the crypt cells.
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