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  • Title: Salicylate and mitochondrial injury in Reye's syndrome.
    Author: You K.
    Journal: Science; 1983 Jul 08; 221(4606):163-5. PubMed ID: 6857275.
    Abstract:
    Electron microscopic and spectrophotometric studies showed that salicylate causes gross swelling of mitochondria in isotonic salt solutions. In overall morphology the salicylate-treated mitochondria resembled those from patients with Reye's syndrome. Salicylate analogs such as m-hydroxybenzoate, p-hydroxybenzoate, and benzoate did not exert this effect. The mitochondria deformed by salicylate tended to return to their original condensed form on removal of the drug.
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